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While these are promising strategies, it is essential that the suggested effects of loss-of-function ATXN3 [71] are well studied in order to evaluate if the beneficial effects outweigh the risks, particularly because ATXN3 gene silencing in some cell types has been shown to cause accumulation of DNA damage, increased proliferation, and loss of adhesion and of differentiation, all of which are hallmarks of cancer [71, 282]

At the highest dose (3/6/9/12 mg escalation scheme), mean HbA1c was reduced by up to 1.6% and weight by nearly 9 kg, which was significantly greater than placebo

However, our BACS test battery revealed minimal changes in cognitive performance between the patients and healthy controls

Tumor cells have decreased ability to metabolize H2O2: Implications for pharmacologic ascorbate in cancer therapy